In-depth analysis of key challenges in Molecular Imaging
Is hybrid SPECT/CT necessary for pre-interventional 3D quantification of relative lobar lung function?
September 10, 2018
Daniela Knollmann et al.
In pulmonary malignancies pre-interventional 3D estimation of relative lobar perfusion is established to predict post-interventional functional outcome particularly in patients with borderline lung function. Aim was to test whether quantification from SPECT-scanners (non-hybrid) is as accurate as from SPECT/CT-scanners (hybrid) when using dedicated software…
August 30, 2018
Fällmar D. et al.
Neuroimaging is a central part of diagnostic work-up of patients with suspected neurodegenerative disease. FDG-PET can reveal pathological changes earlier and more reliably than morphological imaging. Diagnostic accuracy can be improved by constructing 3D SSP Z-score maps, showing patterns of significant deficits. During FDG-PET, the subject receives a moderate but not insignificant dose of ionizing radiation, and a dose reduction with retained image quality is desirable…
June 21, 2018
François Hébert, m.i.t.
Although cancer is likely to affect all parts of the body, it may be more difficult to treat depending on its location. This is particularly the case of unresectable cancers, i.e. cancers that cannot be completely removed by surgery. Liver cancer fits this profile. In addition, this organ has the disadvantage of being particularly sensitive to the radiation of external radiotherapy, so that the dose that can be administered is limited. But a technique, currently used as a last resort, may well change the situation: selective internal radiotherapy, also known as radioembolization…
Spatial normalization of [18F]flutemetamol PET images utilizing an adaptive principal components template
June 14, 2018
Johan Lilja et al.
Though currently approved for visual assessment only, there is evidence to suggest that quantification of amyloid-β (Aβ) PET images may reduce inter-reader variability and aid in the monitoring of treatment effects in clinical trials. Quantification typically involves a regional atlas in standard space, requiring PET images to be spatially normalized. Different uptake patterns in Aβ-positive and Aβ-negative subjects, however, makes spatial normalization challenging. In this study we propose a method to spatially normalize [18F]flutemetamol images, using a synthetic template based on principal component images to overcome these challenges…
April 6, 2018
Benoit Galarneau Eng., M.Sc.A., MBA
Cancer is the insatiable evil of the century. According to the World Health Organization, it caused 8.8 million deaths in 2015. Nearly one in six deaths worldwide is due to this disease. Even worse, the number of new cases is expected to increase by about 70% over the next two decades. Doctors, researchers and scientists are multiplying their efforts and competing ingeniously to try to overcome it, or at least refine the means of detecting, diagnosing and treating it…
March 21, 2018
Tobias Bexelius, Antti Sohlberg
Statistical SPECT reconstruction can be very time-consuming especially when compensations for collimator and detector response, attenuation, and scatter are included in the reconstruction. This work proposes an accelerated SPECT reconstruction algorithm based on graphics processing unit (GPU) processing. Ordered subset expectation maximization (OSEM) algorithm with CT-based attenuation modelling, depth-dependent Gaussian convolution-based collimator-detector response modelling, and Monte Carlo-based scatter compensation was implemented using OpenCL…
February 14, 2018
Matteo Serenari MD, Chiara Bonatti MD, Cinzia Pettinato MD
We recently started to use dynamic 99mTc-mebrofenin hepatobiliary scintigraphy (HBS) combined with Single Photon Emission Computed Tomography/ Computed Tomography (SPECT/CT) in the preoperative evaluation of patients candidate for major hepatic resection. The leading center in Europe in the application of hepatobiliary scintigraphy with SPECT is the Academic Medical Center (Amsterdam The Netherlands), where hepatobiliary scintigraphy data are routinely analyzed by an experienced nuclear medicine physician (R. J. Bennink)…
Phantom and clinical evaluation of the effect of full Monte Carlo collimator modelling in post-SIRT yttrium-90 Bremsstrahlung SPECT imaging
January 22, 2018
Charlotte A. Porter et al.
Post-therapy SPECT/CT imaging of 90Y microspheres delivered to hepatic malignancies is difficult, owing to the continuous, high-energy Bremsstrahlung spectrum emitted by 90Y. This study aimed to evaluate the utility of a commercially available software package (HybridRecon, Hermes Medical Solutions AB) which incorporates full Monte Carlo collimator modelling. Analysis of image quality was performed on both phantom and clinical images in order to ultimately provide a recommendation of an optimum reconstruction for post-therapy 90Y microsphere SPECT/CT imaging….
January 4, 2018
Ran Klein, PhD and Lionel S. Zuckier, MD
The Ottawa Hospital (TOH) has one of the largest nuclear medicine departments in Canada with 8 attending physicians, over twenty technologists, a dozen cameras and 14,000 nuclear imaging exams performed annually (in addition to 9,000 bone mineral density studies). TOH is the product of the amalgamation of three regional hospitals, with the Department of Nuclear Medicine spanning two geographical sites. The University of Ottawa Heart Institute (UOHI) nuclear cardiology group maintains close relations with TOH and performs an addition 6,000 cardiac scans annually…