Anatomically guided reconstruction improves lesion quantitation and detectability in bone SPECT/CTVuohijoki, H, Constable C, Sahlberg AO.
Bone single-photon emission computed tomography (SPECT)/computed tomography (CT) imaging suffers from poor spatial resolution, but the image quality can be improved during SPECT reconstruction by using anatomical information derived from CT imaging.
Comparison of reprojected bone SPECT/CT and planar bone scintigraphy for the detection of bone metastases in breast and prostate cancer.Arvola S, Seppänen M, Malaspina S, Mätzke S, Raiko J, Timonen KL, Ettala O, Jambor I, Anttinen M, Kuisma A, Löyttyniemi E, Boström PJ, Sohlberg A, Noponen T.
The aim of this study was to compare reprojected bone SPECT/CT (RBS) against planar bone scintigraphy (BS) in the detection of bone metastases in breast and prostate cancer patients.
Total Tumor Volume on F18-PSMA-1007 PET as Additional Imaging Biomarker in mCRPC Patients Undergoing PSMA-Targeted Alpha Therapy with Ac.225-PSMA-I&TUnterrainer, L.M.; Beyer, L.; Zacherl, M.J.; Gildehaus, F.J.; Todica, A.; Kunte, S.C.; Holzgreve, A.; Sheikh, G.T.; Herlemann, A.; Casuscelli, J.; Brendel, M.; Albert, N.L.; Wenter, V.; Schmidt-Hegemann, N.-S.; Kunz, W.G.; Cyran, C.C.; Ricke, J.; Stief, C.G.; Bartenstein, P.; Ilhan, H.; Unterrainer, M.
PSMA-based alpha therapy using 225Ac-PSMA-I&T provides treatment for metastatic castration-resistant prostate cancer (mCRPC), even after the failure of 177Lu-PSMA radioligand therapy (RLT). In clinical routine, the total tumor volume (TTV) on PSMA PET impacts therapy outcomes and plays an increasing role in mCRPC patients. Hence, we aimed to assess TTV and its changes during 225Ac-PSMA-I&T RLT.
Comparing calculated and experimental activity and dose values obtained from image-based quantification of Y-90 SPECT/CT Data.Lotter K, Diemling M, Sohlberg A, Wiedner H, Haug A, Maringer FJ.
Selective internal radiation therapy (SIRT) is a treatment for various kinds of liver tumours by injecting Y-90 bearing microspheres into the liver vessels. To perform meaningful post-treatment dosimetry, quantitative imaging is performed.
Feasibility of Different Tumor Delineation Approaches for 18F-PSMA-1007 PET/CT Imaging in Prostate Cancer Patients.Mittlmeier LM, Brendel M, Beyer L, et al.
Delineation of PSMA-positive tumor volume on PET using PSMA-ligands is of highest clinical interest as changes of PSMA-PET/CT-derived whole tumor volume (WTV) have shown to correlate with treatment response in metastatic prostate cancer patients.
Quantitative bone SPECT/CT reconstruction utilizing anatomical informationTuija S. Kangasmaa et al.
Bone SPECT/CT has been shown to offer superior sensitivity and specificity compared to conventional whole-body planar scanning. Furthermore, bone SPECT/CT allows quantitative imaging, which is challenging with planar methods …
Beyond the clot: perfusion imaging of the pulmonary vasculature after COVID-19Ranju T Dhawan et al.
A compelling body of evidence points to pulmonary thrombosis and thromboembolism as a key feature of COVID-19. As the pandemic spread across the globe over the past few months, a timely call to arms was issued by a team of clinicians to consider the prospect of long-lasting pulmonary fibrotic damage and plan for structured follow-up …
Derivation and utility of an Aβ-PET pathology accumulation index to estimate Aβ loadJohan Lilja et al.
To evaluate a novel Aβ-PET based quantitative measure (Aβ accumulation index [Aβ-index]), including the assessment of its ability to discriminate between subjects …
PET amyloid in normal aging: direct comparison of visual and automatic processing methodsSven Haller et al.
Assessment of amyloid deposits is a critical step for the identification of Alzheimer disease (AD) signature in asymptomatic elders. Whether the different amyloid processing methods impacts on the quality of clinico-radiological correlations is still unclear…